Short Communication: Extremely Severe CD4 Lymphopenia During HIV-1 Primary Infection
نویسندگان
چکیده
منابع مشابه
Contribution of immunological and virological factors to extremely severe primary HIV type 1 infection.
BACKGROUND During acute human immunodeficiency virus (HIV) infection, high viral loads and the induction of host immune responses typically coincide with the onset of clinical symptoms. However, clinically severe presentations during acute HIV type 1 (HIV-1) infection, including AIDS-defining symptoms, are unusual. METHODS Virus isolates were tested for clade, drug susceptibility, coreceptor ...
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We investigated whether HIV-1 antigen-specific CD4(+) T cells expressed the viral coreceptor CCR5 during primary HIV-1 infection (PHI). In the peripheral blood of subjects with very early PHI (< 22 days after onset of symptoms), there was a 10- to 20-fold increase in the proportion of highly activated (CD38(+++)) and proliferating (Ki-67(+)) CD4(+) T cells that expressed CCR5(+), and were mostl...
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In this article, we present a fractional order HIV-1 infection model of CD4+ T-cell. We analyze the effect of the changing the average number of the viral particle N with initial conditions of the presented model. The Laplace Adomian decomposition method is applying to check the analytical solution of the problem. We obtain the solutions of the fractional order HIV-1 model in the form of infini...
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Despite all the intense efforts and important progress achieved worldwide by the scientific community and public-health organizations, the HIV pandemic remains without effective solutions. The pathogenic mechanisms underlying the immunodeficiency that follows HIV-1 infection are still poorly understood. This lack of understanding is likely the main reason why at present there is neither a cure ...
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OBJECTIVES IL-2 therapy increases memory and naive CD4 T cells in HIV-infected patients, but its effect on thymopoiesis is unknown. To investigate this effect, we quantified T-cell receptor rearrangement excision circles (TREC) in CD4 T cells from lymphopenic AIDS patients treated with highly active antiretroviral therapy and IL-2. METHODS CD4 cell subsets were evaluated by flow cytometry usi...
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ژورنال
عنوان ژورنال: AIDS Research and Human Retroviruses
سال: 2019
ISSN: 0889-2229,1931-8405
DOI: 10.1089/aid.2019.0065